• Pokrovsky et al. publish in PLoS Biology their study investigating the relationship between the propagation of epigenetic information (histone modification profiles) and the developmental cell proliferation during Xenopus embryogenesis.

    Read More...
  • Getwan et al. publish in PNAS their work studying skeletal ciliopathies. A data mining-based in silico screen found ttc30a to be related to known skeletal ciliopathy genes. CRISPR/Cas9 targeting replicated limb malformations and renal cysts identical to the models of established disease genes.

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  • Maerker et al. published in Nature Communications show that pkd2-mediated post-transcriptional repression dand5 through bicc1 and dicer is a central process in symmetry breaking. Ciliary activity of the calcium channel Pkd2 is crucial for asymmetric leftward flow sensing at the vertebrate left-right organizer.

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  • Animal interphase chromosomes are organized into topologically associating domains (TADs). Niu et al. show that X. tropicalis is a powerful model for chromosome architecture analysis suggesting that chromatin remodeling plays an essential role in de novo TAD establishment. Published in Nature Genetics.

    Read More...
  • An upcoming book to be released by CRC Press.

    Edited by Abraham Fainsood and Sally A. Moody.

     

    Click here to view a PDF flier containing the table of contents. 

     

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  • Xenopus 1 welcomes Nasco frogs.

    Visit Covingtons Customs Rear Contrast-Cut Master Cylinder Cover C1153 for details.

    Travel grants for students interested in attending training courses available.

     

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  • a new registry connecting Scientists and Clinicians

    • Use your Xenopus expertise to help patients and clinicians
    • Boost the clinical significance of your Xenopus research
    • Share your genes of interest
    • Xenopus research is supported by ModelMatcher


    Visit ModelMatcher to register

    Click the link: https://www.modelmatcher.net

     

     

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  • The latest release of Xenbase includes the ability to search for Phenotypes.

     

    Click here to go to the Phenotype search page.

     

    Click here to find details on executing a Phenotype search.

     

    Click here to find details on the Xenopus Phenotype Ontology (XPO).

     

     

    Read More...
  • - available to BLAST

    - view on JBrowse

     

    99.86% of the genome mapped to chromosomes
    ~4500 new and refined models, 18% not present in trop v9.1

     

    Click here to view the release document.

    Read More...
  • The 2020 Xenopus Community White Paper is now available!

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

    Download the 2020 Xenopus White Paper:

    Word Document

    PDF

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  • Pokrovsky et al. publish in PLoS Biology their study investigating the relationship between the propagation of epigenetic information (histone modification profiles) and the developmental cell proliferation during Xenopus embryogenesis.

    Read More...

Xenopus is an essential vertebrate model system for biomedical research

  • Share 83% human disease genes
  • Ease of genomic manipulation
  • Large eggs and embryos with rapid external development
  • Ease of housing
  • Produce hardy eggs year-round
  • Learn more about Xenopus
Adapted from Wheeler & Brändli 2009 Dev Dyn 238:1287-1308" data-original-title="Divergence in time (Mya)" src="/anatomy/static/intro/MOD%20phylogenetic%20tree.png" style="">

The Xenopus model organism knowledgebase
Xenbase is a web-accessible resource that integrates all the diverse biological, genomic, genotype and phenotype data available from Xenopus research. Learn more about Xenbase.

National BioResource Project
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